垂体切除及生长激素替代对大鼠白蛋白合成与分解代谢的影响。
The effect of hypophysectomy and growth hormone replacement on albumin synthesis and catabolism in the rat.
作者信息
Kernoff L M, Pimstone B L, Solomon J, Brock J F
出版信息
Biochem J. 1971 Sep;124(3):529-35. doi: 10.1042/bj1240529.
Abstract
Albumin synthesis and catabolism were respectively measured by McFarlane's (1963) sodium [(14)C]carbonate method and I-labelled albumin in hypophysectomized rats, both untreated and treated with growth hormone. Hypophysectomy resulted in a decrease in both albumin synthesis and catabolic rates. These changes as shown by pair-feeding experiments could not be ascribed to decreased food intake alone. Growth hormone was shown to partially restore both albumin synthesis and catabolic rates. It is proposed that growth hormone stimulates albumin synthesis and that its effect on albumin catabolism is secondary to changes in the mass of the intravascular albumin pool.
摘要
采用麦克法兰（1963年）的碳酸[（14）C]钠法以及用I标记的白蛋白，分别测定了垂体切除大鼠（未治疗组和生长激素治疗组）的白蛋白合成和分解代谢。垂体切除导致白蛋白合成和分解代谢率均下降。成对饲养实验表明，这些变化不能仅归因于食物摄入量的减少。生长激素可部分恢复白蛋白合成和分解代谢率。有人提出，生长激素刺激白蛋白合成，其对白蛋白分解代谢的影响继发于血管内白蛋白池质量的变化。
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