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肌醇六磷酸掺入完整红细胞。I. 含效应物的脂质囊泡与红细胞的融合。

Incorporation of inositol hexaphosphate into intact red blood cells. I. Fusion of effector-containing lipid vesicles with erythrocytes.

作者信息

Nicolau C, Gersonde K

出版信息

Naturwissenschaften. 1979 Nov;66(11):563-6. doi: 10.1007/BF00368810.

DOI:10.1007/BF00368810
PMID:514370
Abstract

Fluid charged lipid vesicles loaded with an inositol hexaphosphate solution were used to transport this allosteric effector into human intact red blood cells. Rate and extent of uptake of the vesicles and of the effector by the red blood cells were measured as changes in the O2 half-saturation pressure and the 31P-NMR spectra of the intracellular inositol hexaphosphate-haemoglobin complex.

摘要

装载有肌醇六磷酸溶液的带电荷脂质囊泡被用于将这种变构效应剂转运到人类完整红细胞中。通过测量细胞内肌醇六磷酸 - 血红蛋白复合物的氧气半饱和压力和31P - NMR谱的变化，来测定红细胞对囊泡和效应剂的摄取速率及摄取程度。

相似文献

1
Incorporation of inositol hexaphosphate into intact red blood cells. I. Fusion of effector-containing lipid vesicles with erythrocytes.肌醇六磷酸掺入完整红细胞。I. 含效应物的脂质囊泡与红细胞的融合。
Naturwissenschaften. 1979 Nov;66(11):563-6. doi: 10.1007/BF00368810.
2
Incorporation of inositol into intact red blood cells. II. Enhancement of gas transport in inositol hexaphosphate-loaded red blood cells.肌醇掺入完整红细胞。II. 六磷酸肌醇负载红细胞中气体运输的增强。
Naturwissenschaften. 1979 Nov;66(11):567-70. doi: 10.1007/BF00368811.
3
Incorporation of inositol hexaphosphate into red blood cells mediated by dimethyl sulfoxide.由二甲基亚砜介导的肌醇六磷酸掺入红细胞。
Life Sci. 1983 Jun 13;32(24):2763-8. doi: 10.1016/0024-3205(83)90397-1.
4
Modification of partial pressure of oxygen (P50) in mammalian red blood cells by incorporation of an allosteric effector of hemoglobin.通过掺入血红蛋白的变构效应剂来改变哺乳动物红细胞中的氧分压（P50）。
Biotechnol Appl Biochem. 1989 Feb;11(1):31-40. doi: 10.1111/j.1470-8744.1989.tb00049.x.
5
Oxygen transport to tissue modified by entrapment of an allosteric effector of haemoglobin in erythrocytes.通过将血红蛋白的变构效应剂包封在红细胞中来改变组织的氧运输。
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(4):488-92.
6
Long-term physiological effects of enhanced O2 release by inositol hexaphosphate-loaded erythrocytes.富含肌醇六磷酸的红细胞增强氧气释放的长期生理效应。
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6894-8. doi: 10.1073/pnas.84.19.6894.
7
Incorporation of inositol hexaphosphate in stored erythrocytes: effect on tissue oxygenation.在储存红细胞中加入肌醇六磷酸：对组织氧合的影响。
Life Support Syst. 1985;3 Suppl 1:458-61.
8
Improvement of the red blood cell O2 release capacity by lipid vesicle-mediated incorporation of inositol hexaphosphate.通过脂质囊泡介导掺入肌醇六磷酸来提高红细胞的氧释放能力。
Blut. 1979 Jul;39(1):1-7. doi: 10.1007/BF01008069.
9
Encapsulation of a hemoglobin allosteric effector in erythrocytes: in vivo results.红细胞中血红蛋白变构效应剂的包封：体内结果
Life Support Syst. 1984 Oct-Dec;2(4):277-80.
10
Preparation of low-affinity red cells with dimethylsulfoxide-mediated inositol hexaphosphate incorporation: hemoglobin and ATP recovery using a continuous-flow method.利用二甲基亚砜介导的肌醇六磷酸掺入法制备低亲和力红细胞：采用连续流动法回收血红蛋白和三磷酸腺苷
Am J Hematol. 1984;17(4):393-400. doi: 10.1002/ajh.2830170409.

引用本文的文献

1
Erythrocytes as Carriers: From Drug Delivery to Biosensors.红细胞作为载体：从药物递送 to 生物传感器。 （注：这里“to”原文有误，可能应是“到”的意思，按照正确理解完整译文应该是“红细胞作为载体：从药物递送到生物传感器” ）
Pharmaceutics. 2020 Mar 18;12(3):276. doi: 10.3390/pharmaceutics12030276.
2
Recent advancements in erythrocytes, platelets, and albumin as delivery systems.红细胞、血小板和白蛋白作为递送系统的最新进展。
Onco Targets Ther. 2016 May 17;9:2873-84. doi: 10.2147/OTT.S104691. eCollection 2016.
3
Drug-loaded erythrocytes: on the road toward marketing approval.载药红细胞：迈向上市批准之路。

本文引用的文献

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Viropexis, the mechanism of influenza virus infection.病毒入胞作用，即流感病毒感染的机制。
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Method for continuous registration of O2-binding curves of hemoproteins by means of a diffusion chamber.通过扩散室连续记录血红蛋白O2结合曲线的方法。
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Improvement of the red blood cell O2 release capacity by lipid vesicle-mediated incorporation of inositol hexaphosphate.通过脂质囊泡介导掺入肌醇六磷酸来提高红细胞的氧释放能力。
Blut. 1979 Jul;39(1):1-7. doi: 10.1007/BF01008069.
5
Incorporation of inositol into intact red blood cells. II. Enhancement of gas transport in inositol hexaphosphate-loaded red blood cells.肌醇掺入完整红细胞。II. 六磷酸肌醇负载红细胞中气体运输的增强。
Naturwissenschaften. 1979 Nov;66(11):567-70. doi: 10.1007/BF00368811.
正常淋巴细胞和恶性淋巴瘤细胞表面膜脂质层中不同胆固醇水平所诱导的微粘度差异。
J Mol Biol. 1974 Jan 5;85(4):603-15. doi: 10.1016/0022-2836(74)90318-0.
4
Characteristics of the permeability barrier of human erythrocyte ghosts to non-electrolytes.人红细胞血影对非电解质的通透屏障特性
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5
Microviscosity and order in the hydrocarbon region of phospholipid and phospholipid-cholesterol dispersions determined with fluorescent probes.用荧光探针测定磷脂及磷脂 - 胆固醇分散体系烃类区域的微粘度和有序性。
Biochemistry. 1973 Jan 30;12(3):521-8. doi: 10.1021/bi00727a026.
6
Membrane fusion.膜融合
Biochim Biophys Acta. 1973 Dec 28;300(4):421-65. doi: 10.1016/0304-4157(73)90015-4.
7
Association of glyceraldehyde 3-phosphate dehydrogenase with the human erythrocyte membrane. Effect of detergents, trypsin, and adenosine triphosphate.3-磷酸甘油醛脱氢酶与人类红细胞膜的关联。去污剂、胰蛋白酶和三磷酸腺苷的作用。
J Biol Chem. 1973 Feb 25;248(4):1436-44.
8
Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.人红细胞膜主要多肽的电泳分析。
Biochemistry. 1971 Jun 22;10(13):2606-17. doi: 10.1021/bi00789a030.
9
Interaction of hemoglobin with ions. Allosteric effects of the binding of anions.血红蛋白与离子的相互作用。阴离子结合的变构效应。
Biochim Biophys Acta. 1971 Apr 27;236(1):211-21. doi: 10.1016/0005-2795(71)90168-1.
10
Thermodynamical studies of oxygen equilibrium of hemoglobin. Nonuniform heats and entropy changes for the individual oxygenation steps and enthalpy-entropy compensation.血红蛋白氧平衡的热力学研究。各个氧合步骤的非均匀热和熵变以及焓-熵补偿。
J Biol Chem. 1975 Sep 25;250(18):7093-8.