Champion H R, Wallace I W
Br J Cancer. 1971 Sep;25(3):441-8. doi: 10.1038/bjc.1971.56.
Histological sections of the primary tumour from 496 women with operable breast cancer have been examined for purposes of histological grading by two observers working independently. Each found a similar distribution of grade through the series, and a virtually identical influence of grade on prognosis. This close agreement occurred despite a 30% disagreement as to grade in individual cases. It is suggested therefore, that this technique while of relevance to analysis of groups of cases is of very limited reliability in individual patient prognosis.
496例可手术乳腺癌患者的原发肿瘤组织切片由两名独立工作的观察者进行组织学分级检查。两人均发现整个系列中分级分布相似，且分级对预后的影响几乎相同。尽管在个别病例的分级上存在30%的分歧，但仍达成了如此高度的一致。因此，有人认为，这项技术虽然与病例组分析相关，但在个体患者预后方面的可靠性非常有限。
