Champion H R, Wallace I W, Prescott R J
Br J Cancer. 1972 Apr;26(2):129-38. doi: 10.1038/bjc.1972.19.
Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of axillary nodes, have been related to survival.It was found that prognosis was worse in patients with a high grade tumour and in those with histological evidence of axillary node spread. Round cell infiltration of the primary tumour did not confer improved survival.The clinical state of the axillary nodes was associated with prognosis in so far that palpable nodes were twice as commonly the seat of metastatic spread as were impalpable nodes.
对500例可手术切除的浸润性乳腺癌女性患者的原发肿瘤及同侧腋窝淋巴结进行了组织学切片检查。对肿瘤进行了分级，并评估了圆形细胞浸润程度。这些特征，连同腋窝淋巴结的临床可触及性和病理累及情况，均与生存率相关。结果发现，高级别肿瘤患者以及有腋窝淋巴结转移组织学证据的患者预后较差。原发肿瘤的圆形细胞浸润并未带来生存率的提高。腋窝淋巴结的临床状态与预后相关，因为可触及的淋巴结发生转移扩散的几率是不可触及淋巴结的两倍。
