Sellars W A, Pflanzer J
South Med J. 1975 Aug;68(8):970-5. doi: 10.1097/00007611-197508000-00009.
Thirty-six asthmatic children received placebo and cromolyn sodium, a new drug, in a double-blind crossover study; the majority were not using corticosteroids. Significant decreases in wheezing, breathlessness at rest, and cough occurred when the active drug was compared to placebo. Marked preference for cromolyn over placebo was expressed at the end of the study. Our results agree with previous reports on the effectiveness of cromolyn sodium. We found this drug to be especially useful as an adjunct to other treatment in the control of asthmatic children.
在一项双盲交叉研究中,36名哮喘儿童接受了安慰剂和一种新药色甘酸钠的治疗;大多数儿童未使用皮质类固醇。与安慰剂相比,使用活性药物后喘息、静息时呼吸困难和咳嗽显著减轻。在研究结束时,患儿对色甘酸钠的偏好明显高于安慰剂。我们的结果与之前关于色甘酸钠有效性的报告一致。我们发现这种药物作为其他治疗的辅助手段,在控制哮喘儿童病情方面特别有用。