大鼠血小板内Na⁺-K⁺与¹⁴C-5-羟色胺积累之间的关系。
Relationship between internal Na + -K + and the accumulation of 14 C-5-hydroxytryptamine by rat platelets.
作者信息
Sneddon J M
出版信息
Br J Pharmacol. 1971 Dec;43(4):834-44. doi: 10.1111/j.1476-5381.1971.tb07220.x.
Abstract
- 5-Hydroxytryptamine (5-HT) transport has been investigated in rat blood platelets poisoned with dinitrophenol-sodium fluoride or ouabain.2. The inhibition of transport produced by different concentrations of the metabolic inhibitors has been correlated with changes in the internal Na(+) and K(+) concentrations of the platelets.3. Platelets poisoned in a high K(+) medium maintained a high internal K(+) concentration in the absence of cellular metabolism. When transferred to Krebs solutions containing different concentrations of Na(+) they accumulated 5-HT by a process that was related to the magnitudes of the internal and external Na(+) concentrations.4. The results are consistent with the hypothesis that the spontaneous movement of ions through the platelet membrane is capable of providing, at least in part, the energy requirements for 5-HT transport.
摘要
已对用二硝基苯酚 - 氟化钠或哇巴因中毒的大鼠血小板中的5 - 羟色胺（5 - HT）转运进行了研究。
不同浓度代谢抑制剂所产生的转运抑制作用已与血小板内Na(+)和K(+)浓度的变化相关联。
在高K(+)培养基中中毒的血小板在无细胞代谢的情况下维持较高的细胞内K(+)浓度。当转移至含有不同浓度Na(+)的 Krebs 溶液中时，它们通过与细胞内和细胞外Na(+)浓度大小相关的过程积累5 - HT。
这些结果与以下假设一致，即离子通过血小板膜的自发移动至少部分能够提供5 - HT转运所需的能量。
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