大鼠血小板对5-羟色胺的钠依赖性积累。
Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets.
作者信息
Sneddon J M
出版信息
Br J Pharmacol. 1969 Nov;37(3):680-8. doi: 10.1111/j.1476-5381.1969.tb08506.x.
Abstract
- The influence of sodium and potassium on the accumulation of 5-hydroxytryptamine (5-HT) by rat blood platelets was investigated.2. An absolute dependence of 5-HT uptake on the sodium concentration in the medium was found.3. Removal of potassium reduced the uptake by about 60%. High concentrations of potassium inhibited sodium-dependent accumulation.4. The observations have been discussed in terms of a carrier-mediated transport process for 5-HT operating in the platelet membrane.
摘要
研究了钠和钾对大鼠血小板积累5-羟色胺（5-HT）的影响。
发现5-HT摄取对培养基中钠浓度存在绝对依赖性。
去除钾使摄取减少约60%。高浓度钾抑制钠依赖性积累。
已根据血小板膜中5-HT的载体介导转运过程对这些观察结果进行了讨论。
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