组织胞浆菌病中的淋巴细胞介导的细胞免疫
Lymphocyte-mediated cellular immunity in histoplasmosis.
作者信息
Howard D H, Otto V, Gupta R K
出版信息
Infect Immun. 1971 Nov;4(5):605-10. doi: 10.1128/iai.4.5.605-610.1971.
Abstract
Mononuclear phagocytes freshly harvested from immunized animals restrict the intracellular growth of Histoplasma capsulatum, whereas the same cells maintained in culture for 48 hr do not. Experiments established that within the mixed cell population of the mouse peritoneal cavity the lymphocyte was the most likely mediator of the intracellular growth restriction observed. Partially purified lymphocytes, from the peritoneal cavity of mice immunized by sublethal infection, mediated the suppression of intracellular growth of the fungus in normal mouse macrophages in cell culture.
摘要
从免疫动物新鲜分离的单核吞噬细胞可限制荚膜组织胞浆菌的细胞内生长，而在培养中维持48小时的相同细胞则不能。实验证实，在小鼠腹腔的混合细胞群体中，淋巴细胞最有可能是观察到的细胞内生长限制的介导者。从经亚致死感染免疫的小鼠腹腔中部分纯化的淋巴细胞，在细胞培养中可介导对正常小鼠巨噬细胞内真菌生长的抑制。
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