感染布氏锥虫和罗德西亚锥虫的家兔的细胞介导超敏反应。
Cell-mediated hypersensitivity in rabbits infected with Trypanosoma brucei and Trypanosoma rhodesiense.
作者信息
Tizard I R, Soltys M A
出版信息
Infect Immun. 1971 Dec;4(6):674-7. doi: 10.1128/iai.4.6.674-677.1971.
Animals infected with strains of Trypanosoma brucei and T. rhodesiense exhibited cutaneous hypersensitivity to intradermal administration of antigen. This reactivity was of two types, an Arthus-type, antibody-mediated reaction which reached maximum intensity 4 hr after injection and a delayed-type, cell-mediated reaction which reached maximum intensity 24 hr after injection. This delayed-type hypersensitivity appeared in rabbits not earlier than 3 weeks after onset of infection. It did not occur in animals which received dead organisms. There was a cross-reaction in both types of reactivity between antigens prepared from T. brucei and T. rhodesiense. The delayed-type hypersensitivity was transferred to normal rabbits by intravenous inoculation of washed living cells from the spleen of a rabbit which showed delayed hypersensitivity. Dead cells failed to transfer hypersensitivity. The histological picture of the indurated area was typical of a delayed-type reaction.
感染布氏锥虫和罗德西亚锥虫菌株的动物，对皮内注射抗原表现出皮肤超敏反应。这种反应有两种类型，一种是阿图斯型抗体介导反应，注射后4小时达到最大强度；另一种是迟发型细胞介导反应，注射后24小时达到最大强度。这种迟发型超敏反应在兔子身上最早在感染开始后3周才出现。在接受死病原体的动物中未出现这种反应。从布氏锥虫和罗德西亚锥虫制备的抗原在两种反应类型中均存在交叉反应。通过静脉接种来自表现出迟发型超敏反应的兔子脾脏的洗涤活细胞，可将迟发型超敏反应转移至正常兔子。死细胞无法转移超敏反应。硬结区域的组织学图像是典型的迟发型反应。
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