Huang S M, Huang Y C, Chiou W L
Res Commun Chem Pathol Pharmacol. 1979 Oct;26(1):115-27.
Using a sensitive high-pressure liquid chromatographic method for the determination of gentamicin, plasma-level profiles of gentamicin were found to fit to a triexponential equation in 3 out of 4 rabbits studied after bolus intravenous administration by the application of the Minimum Akaike's Information Criterion Estimation (MAICE) method. This is different from the monoexponential or biexponential decay of gentamicin often reported in humans. Volumes of distribution of central compartment and at the steady-state in rabbits were similar to those reported in humans. Extensive distribution and tissue binding of gentamicin in rabbits were indicated by their high Vdarea, about 3.9 l/kg. It is proposed that rabbits may serve as a useful model for studying the mechanism and prediction of renal toxicity of gentamicin in patients.
采用灵敏的高压液相色谱法测定庆大霉素，在4只家兔静脉推注给药后，应用最小赤池信息量准则估计（MAICE）方法，发现其中3只家兔的庆大霉素血药浓度曲线符合三指数方程。这与人类中经常报道的庆大霉素单指数或双指数衰减不同。家兔中央室和稳态时的分布容积与人类报道的相似。家兔中庆大霉素的高Vdarea（约3.9 l/kg）表明其在体内广泛分布并与组织结合。有人提出，家兔可作为研究庆大霉素对患者肾毒性机制及预测的有用模型。
