甲基化后抑制DNA合成的一种新机制：N-甲基-N-亚硝基脲对HeLa细胞的作用。 - Suppr

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超能文献

A novel mechanism for the inhibition of DNA synthesis following methylation: the effect of N-methyl-N-nitrosourea on HeLa cells.

作者信息

Plant J E, Roberts J J

出版信息

Chem Biol Interact. 1971 Oct;3(5):337-42. doi: 10.1016/0009-2797(71)90013-5.

DOI:10.1016/0009-2797(71)90013-5

PMID:5156328

Abstract

摘要

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A novel mechanism for the inhibition of DNA synthesis following methylation: the effect of N-methyl-N-nitrosourea on HeLa cells.甲基化后抑制DNA合成的一种新机制：N-甲基-N-亚硝基脲对HeLa细胞的作用。

Chem Biol Interact. 1971 Oct;3(5):337-42. doi: 10.1016/0009-2797(71)90013-5.

Quantitative aspects of the repair of alkylated DNA in cultured mammalian cells. II. Non-semiconservative DNA synthesis ('repair synthesis') in HeLa and Chinese hamster cells following treatment with alkylating agents.培养的哺乳动物细胞中烷基化DNA修复的定量研究。II. 用烷基化剂处理后HeLa细胞和中国仓鼠细胞中的非半保留DNA合成（“修复合成”）

Chem Biol Interact. 1971 Feb;3(1):49-68. doi: 10.1016/0009-2797(71)90025-1.

Inhibition of post-replication repair of alkylated DNA by caffeine in Chinese hamster cells but not HeLa cells.

Chem Biol Interact. 1973 Oct;7(4):241-64. doi: 10.1016/0009-2797(73)90027-6.

Extension of the pre-DNA synthetic phase of the cell cycle as a consequence of DNA alkylation in Chinese hamster cells: a possible mechanism of DNA repair.中国仓鼠细胞中DNA烷基化导致细胞周期DNA合成前期延长：一种可能的DNA修复机制

Chem Biol Interact. 1971 Oct;3(5):343-51. doi: 10.1016/0009-2797(71)90014-7.

Repair of alkylated DNA in mammalian cells.

Johns Hopkins Med J Suppl. 1972(1):226-38.

The enhancement by caffeine of alkylation-induced cell death, mutations and chromosomal aberrations in Chinese hamster cells, as a result of inhibition of post-replication DNA repair.咖啡因通过抑制复制后DNA修复，增强了烷化剂诱导的中国仓鼠细胞的细胞死亡、突变和染色体畸变。

Mutat Res. 1974 Apr;26(2):129-43. doi: 10.1016/s0027-5107(74)80043-6.

Initial cell cycle delay and depression of macromolecular synthesis of primary mouse embryo cells treated with methylnitrosourea in mass culture.在大规模培养中用甲基亚硝基脲处理的原代小鼠胚胎细胞的初始细胞周期延迟和大分子合成抑制。

Exp Cell Res. 1972 Jan;70(1):49-56. doi: 10.1016/0014-4827(72)90180-2.

N-methyl-N'-nitro-N-nitrosoguanidine: reactions of possible significance to biological activity with mammalian cells.N-甲基-N'-硝基-N-亚硝基胍：与哺乳动物细胞发生的可能对生物活性具有重要意义的反应。

Cancer Res. 1970 Jun;30(6):1773-81.

Sensitivity of confluent and cycling embryonic hamster cells to sulfur mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and actinomycin D.

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Repair of alkylation damage in ultraviolet-sensitive (xeroderma pigmentosum) human cells.紫外线敏感型（着色性干皮病）人类细胞中烷基化损伤的修复

Mutat Res. 1971 Aug;12(4):453-62. doi: 10.1016/0027-5107(71)90095-9.

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Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide.修复途径之间的串扰会导致烷基化 DNA 中的双链断裂，并对替莫唑胺的作用产生影响。

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Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells.胶质母细胞瘤细胞中DNA损伤反应信号与DNA损伤的解偶联是替莫唑胺耐药的基础。

J Biomed Res. 2010 Nov;24(6):424-35. doi: 10.1016/S1674-8301(10)60057-7.

Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA.错配修复依赖的甲基化损伤处理会在新复制的DNA中产生持续的单链缺口。

Genes Dev. 2007 Dec 15;21(24):3342-55. doi: 10.1101/gad.455407.

Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.低剂量SN1型甲基化剂诱导的错配修复依赖性G2期检查点需要ATR激酶。

Genes Dev. 2004 Jun 1;18(11):1331-44. doi: 10.1101/gad.294404.

Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.错配修复能力可阻止经N-甲基-N'-硝基-N-亚硝基胍处理的癌细胞发生克隆性扩增。

J Clin Invest. 1996 Jul 1;98(1):199-206. doi: 10.1172/JCI118767.

Direct measurement of cyclic current-voltage responses of integral membrane proteins at a self-assembled lipid-bilayer-modified electrode: cytochrome f and cytochrome c oxidase.在自组装脂质双层修饰电极上直接测量完整膜蛋白的循环电流-电压响应：细胞色素f和细胞色素c氧化酶。

Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6420-3. doi: 10.1073/pnas.90.14.6420.

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.一种耐烷基化的突变型人类细胞系在链特异性错配修复方面存在缺陷。

Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6424-8. doi: 10.1073/pnas.90.14.6424.

Different cytotoxic effects of methyl- and ethylnitrosourea on developing rat tissues and the influence of cycloheximide on cell death.甲基亚硝基脲和乙基亚硝基脲对发育中大鼠组织的不同细胞毒性作用以及环己酰亚胺对细胞死亡的影响。

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 Jun 19;79(4):255-66. doi: 10.1007/BF00304018.

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.哺乳动物细胞对烷基化损伤的抗性中的自我破坏与耐受性

Nucleic Acids Res. 1992 Jun 25;20(12):2933-40. doi: 10.1093/nar/20.12.2933.

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