利福平诱导的人及豚鼠肝细胞滑面内质网的变化
Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes.
作者信息
Jezequel A M, Orlandi F, Tenconi L T
出版信息
Gut. 1971 Dec;12(12):984-7. doi: 10.1136/gut.12.12.984.
Abstract
Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.
摘要
利福平可诱导豚鼠和人肝细胞中滑面内质网增殖。这可能支持药物诱导药物代谢酶增强的假说。然而，人和豚鼠肝细胞中的增殖模式并不相似。在人体酶诱导研究以及从动物数据外推至人体数据时需要谨慎。
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