药物从蛋白结合位点的置换：体内一种再分布性药物相互作用的分离
Drug displacement from protein binding: isolation of a redistributional drug interaction in vivo.
作者信息
McQueen E G, Wardell W M
出版信息
Br J Pharmacol. 1971 Oct;43(2):312-24.
Abstract
- The pharmacokinetic interaction between phenylbutazone and sulphadoxine has been studied in live sheep.2. Intravenous injection of phenylbutazone causes a rapid fall in the concentration of total sulphadoxine together with a simultaneous rise in the concentration of free sulphadoxine in plasma. Both processes are complete within 3 min of the injection of phenylbutazone.3. These reciprocal changes in the concentrations of total and free sulphadoxine in plasma do not depend on changes in the absorption, hepatic metabolism or renal excretion of sulphadoxine. By exclusion therefore, it is concluded that the effect of phenylbutazone in this interaction is solely to cause redistribution of the sulphadoxine.
摘要
已在活羊身上研究了保泰松与磺胺多辛之间的药代动力学相互作用。
静脉注射保泰松会导致血浆中总磺胺多辛浓度迅速下降，同时游离磺胺多辛浓度同步上升。这两个过程在注射保泰松后的3分钟内完成。
血浆中总磺胺多辛和游离磺胺多辛浓度的这些相互变化并不取决于磺胺多辛的吸收、肝脏代谢或肾脏排泄的变化。因此，通过排除法得出结论，保泰松在这种相互作用中的作用仅仅是引起磺胺多辛的重新分布。
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