局部应用皮质类固醇对小鼠接触性敏感反应的抑制作用。
Inhibition of contact sensitivity in the mouse by topical application of corticosteroids.
作者信息
Evans D P, Hossack M, Thomson D S
出版信息
Br J Pharmacol. 1971 Oct;43(2):403-8.
Abstract
- Topical application of oxazolone to the ears of mice previously sensitized to this hapten resulted in a marked increase in ear weight 24 h later.2. Topical application of hydrocortisone, betamethasone 17-valerate, fluocinolone acetonide or triamcinolone acetonide inhibited this response in a dose dependent manner.3. The free alcohols of the three fluorinated compounds were only weakly active.4. Activity in this model was truly local. Oral administration of hydrocortisone or fluocinolone acetonide at doses comparable to those used topically failed to inhibit the ear swelling.5. Some steroids with poor anti-inflammatory properties had no significant effect.
摘要
对先前已对半抗原恶唑酮致敏的小鼠耳部进行恶唑酮局部涂抹，24小时后耳部重量显著增加。
局部涂抹氢化可的松、倍他米松17 - 戊酸酯、醋酸氟轻松或曲安奈德可剂量依赖性地抑制该反应。
三种含氟化合物的游离醇活性较弱。
该模型中的活性是真正局部性的。口服与局部使用剂量相当的氢化可的松或醋酸氟轻松未能抑制耳部肿胀。
一些抗炎特性较差的类固醇没有显著作用。
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本文引用的文献
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2
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J Pharm Sci. 1965 Mar;54:335-54. doi: 10.1002/jps.2600540302.
3
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Arch Dermatol. 1964 May;89:741-6. doi: 10.1001/archderm.1964.01590290107016.
4
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Endocrinology. 1965 Oct;77(4):625-34. doi: 10.1210/endo-77-4-625.
5
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