三甲氧苯乙胺引起的大脑皮质核糖体变化。精脒在对抗三甲氧苯乙胺对大脑皮质核糖体的去稳定作用中的作用。
Mescaline-induced changes of brain-cortex ribosomes. Role of sperimidine in counteracting the destabilizing effect of mescaline of brain-cortex ribosomes.
作者信息
Datta R K, Antopol W, Ghosh J J
出版信息
Biochem J. 1971 Nov;125(1):213-9. doi: 10.1042/bj1250213.
Abstract
- The effect of spermidine on the mescaline-induced changes of brain-cortex ribosomes was studied by adding spermidine during the treatment of goat brain-cortex slices with mescaline. 2. Mescaline treatment of brain-cortex slices removed a portion of the endogenous spermidine from ribosomes and this removal was significantly prevented when spermidine was present during mescaline treatment. 3. Spermidine present during mescaline treatment of brain-cortex slices counteracted, to some extent, the destabilizing effect of mescaline on ribosomes with respect to heat denaturation. 4. Mescaline treatment of brain-cortex slices made ribosomes more susceptible to breakdown, releasing protein and RNA, and resulting in loss of ribosomal enzymic activities. However, spermidine present during mescaline treatment counteracted moderately the mescaline-induced ribosomal susceptibility to breakdown and ribosomal loss of enzymic activities. 5. Ribosomes of mescaline-treated cortex slices were rapidly degraded by ribonuclease and trypsin. However, if spermidine was present during mescaline treatment of brain-cortex slices the rates of degradation diminished.
摘要
- 通过在使用麦司卡林处理山羊脑皮质切片的过程中添加亚精胺，研究了亚精胺对麦司卡林诱导的脑皮质核糖体变化的影响。2. 用麦司卡林处理脑皮质切片会使核糖体中的一部分内源性亚精胺去除，而当在麦司卡林处理期间存在亚精胺时，这种去除会被显著阻止。3. 在使用麦司卡林处理脑皮质切片期间存在的亚精胺，在一定程度上抵消了麦司卡林对核糖体热变性的不稳定作用。4. 用麦司卡林处理脑皮质切片会使核糖体更容易分解，释放蛋白质和RNA，并导致核糖体酶活性丧失。然而，在麦司卡林处理期间存在的亚精胺适度抵消了麦司卡林诱导的核糖体对分解的敏感性以及核糖体酶活性的丧失。5. 用麦司卡林处理的皮质切片的核糖体被核糖核酸酶和胰蛋白酶迅速降解。然而，如果在使用麦司卡林处理脑皮质切片期间存在亚精胺，降解速率会降低。
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引用本文的文献
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Naunyn Schmiedebergs Arch Pharmacol. 1973;277(3):319-22. doi: 10.1007/BF00505670.
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