Wide M, Nilsson B O
Teratology. 1979 Aug;20(1):101-13. doi: 10.1002/tera.1420200114.
Implantation chambers, trophoblast and uterine luminal surfaces were examined on days 5 and 6 of pregnancy by electron microscopy in mice with implantation failure due to an intravenous injection of 75 ppm of lead chloride on day 4. Attachment of the trophoblast cells to the surface of the endometrium and closure of the uterine lumina had failed to occur. Uterine epithelial cells in implantation chambers and along the lumina were covered with abundant microvilli. This appearance is similar to that seen in mice in experimental delay of implantation before the oestrogen-induced attachment of the blastocyst has occurred. It may therefore be assumed that lead has in some way interfered with the activity of ovarian steroid hormones on the endometrium. No significant changes were observed in surface ultrastructure of the blastocysts from the lead-treated and control groups.
在妊娠第5天和第6天，通过电子显微镜检查了因在第4天静脉注射75 ppm氯化铅而导致植入失败的小鼠的植入腔、滋养层和子宫腔表面。滋养层细胞未能附着于子宫内膜表面，子宫腔也未闭合。植入腔内和沿腔的子宫上皮细胞覆盖着丰富的微绒毛。这种外观类似于在雌激素诱导囊胚附着之前实验性植入延迟的小鼠中所观察到的。因此可以推测，铅以某种方式干扰了卵巢甾体激素对子宫内膜的作用。在铅处理组和对照组的囊胚表面超微结构中未观察到显著变化。
