Nilsson B O, Ljung L, Wide M
Department of Human Anatomy, Biomedical Centre, Uppsala, Sweden.
Arch Toxicol. 1991;65(3):239-43. doi: 10.1007/BF02307315.
Mice in experimental delay of implantation were injected intravenously with 75 micrograms.g-1 body weight of lead chloride, corresponding to a dose of lead of about 56 micrograms.g-1 body weight. Delay of implantation was obtained by ovariectomy 3 days after mating followed by a depot dose of progesterone every fifth day. Electron microscopy showed that the uterine lumen, which was closed in control mice, was opened in lead-injected mice. This morphology suggested that lead caused an increase in uterine secretion. X-ray microanalysis of pyroantimonate precipitates in the uterine epithelium of injected mice demonstrated lead in the precipitates, suggesting that lead could have a direct effect on the function of the uterine epithelium and that lead also could be secreted into the uterine lumen and affect the blastocysts.
对处于实验性植入延迟状态的小鼠静脉注射每克体重75微克的氯化铅，相当于每克体重约56微克的铅剂量。通过在交配后3天进行卵巢切除术，随后每隔5天注射一次长效孕酮来实现植入延迟。电子显微镜检查显示，对照小鼠中封闭的子宫腔在注射铅的小鼠中是开放的。这种形态表明铅导致子宫分泌增加。对注射小鼠子宫上皮中焦锑酸盐沉淀物的X射线微分析表明沉淀物中有铅，这表明铅可能对子宫上皮功能有直接影响，并且铅也可能分泌到子宫腔中并影响胚泡。
