脑区室的模拟研究。小鼠脑中谷氨酸及相关物质的代谢。
A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain.
作者信息
van den Berg C J, Garfinkel D
出版信息
Biochem J. 1971 Jun;123(2):211-8. doi: 10.1042/bj1230211.
Abstract
A computer model of the metabolism of glutamate, glutamine, gamma-aminobutyrate, and the tricarboxylic acid cycle in mouse brain has been constructed in terms of 39 reactions among 19 substances or groups of substances (permitting manipulation of 30 independent variables). The model is divided into two compartments, in conformity with previous models based on indirect evidence, and it is found that this compartmentation is indeed the same as that indicated directly with specifically (14)C-labelled acetate and glucose. The movement of materials between the large and small compartments has been studied; glutamine appears to flow from the small to the large compartment, gamma-aminobutyrate in the reverse direction.
摘要
已经构建了一个小鼠大脑中谷氨酸、谷氨酰胺、γ-氨基丁酸和三羧酸循环代谢的计算机模型，该模型涉及19种物质或物质组之间的39个反应（允许操纵30个独立变量）。与基于间接证据的先前模型一致，该模型分为两个区室，并且发现这种区室划分确实与用特定的（14）C标记的乙酸盐和葡萄糖直接指示的相同。已经研究了大小区室之间的物质流动；谷氨酰胺似乎从小区室流向大区室，γ-氨基丁酸则相反。
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