Mayer D J, Wolfle T L, Akil H, Carder B, Liebeskind J C
Science. 1971 Dec 24;174(4016):1351-4. doi: 10.1126/science.174.4016.1351.
Stimulation at several mesencephalic and diencephalic sites abolished responsiveness to intense pain in rats while leaving responsiveness to other sensory modes relatively unaffected. The peripheral field of analgesia was usually restricted to one-half or to one quadrant of the body, and painful stimuli applied outside this field elicited a normal reaction. Analgesia outlasted stimulation by up to 5 minutes. Most electrode placements that produced analgesia also supported self-stimulation. One placement supported self-stimulation only in the presence of pain.
刺激大鼠中脑和间脑的几个部位可消除其对强烈疼痛的反应，而对其他感觉模式的反应相对不受影响。镇痛的外周区域通常局限于身体的一半或一个象限，在此区域之外施加的疼痛刺激会引发正常反应。镇痛作用比刺激持续时间长可达5分钟。大多数产生镇痛作用的电极位置也支持自我刺激。有一个位置仅在疼痛存在时才支持自我刺激。
