Shestakova S A
Acta Biol Med Ger. 1979;38(1):47-51.
In leukocytes of exudate from diabetic rabbits, the activities of hexokinase, phosphoglucomutase and glucose-6-phosphate dehydrogenase are increased, and a tendency of adenylate kinase activity to decline is observable. The activities of UDP-pyrophosphatase, UDP-glycogentransferase, 6-phosphogluconate dehydrogenase and glutahione reductase in the exudate erythrocytes in diabetes are not essentially altered. The decrease of the key enzymes of glycolysis and pentose phosphate cycle, providing the leukocytes with energy and metabolites, reduces the functional activity of leukocytes from exudate in diabetes.
在糖尿病兔渗出液的白细胞中,己糖激酶、磷酸葡萄糖变位酶和葡萄糖-6-磷酸脱氢酶的活性增加,腺苷酸激酶活性有下降趋势。糖尿病时渗出液红细胞中尿苷二磷酸焦磷酸酶、尿苷二磷酸糖原转移酶、6-磷酸葡萄糖酸脱氢酶和谷胱甘肽还原酶的活性基本未改变。糖酵解和磷酸戊糖循环关键酶的减少,使白细胞获得能量和代谢产物减少,从而降低了糖尿病时渗出液中白细胞的功能活性。