[Effect of diet on deiodination of L-diiodotyrosine and L-thyroxine in rat liver].

Male Wistar rats of same weight were used to study the effects of diets containing, respectively, 3 and 50 per cent (by weight) fat on the deiodination of L-di-iodotyrosine and L-thyroxin in the liver. For this purpose, liver homogenate supernatants were analysed. The deiodination of L-di-iodotyrosine was significantly lower in the animals on high-fat diet than in those on low-fat diet, whereas the deiodination of L-thyroxin was significantly higher. It is concluded that not the body weight, but the diet influences the extent of deiodination.