Fogh-Andersen P
Birth Defects Orig Artic Ser. 1971 Jun;7(7):50-3.
Epidemiologic and etiologic studies based on the international literature and Danish observations of 4500 patients show a steadily increasing incidence of human cleft deformities at birth. The incidence at present is nearly 2 per 1000. Heredity is the most important etiologic factor and is probably responsible for 25 to 50% of the cases depending on the type of cleft, whereas the influence of exogenous factors is still of unknown nature. Empiric risk figures and some examples of cleft syndromes are presented.
基于国际文献以及丹麦对4500名患者的观察结果所开展的流行病学和病因学研究表明，人类出生时出现腭裂畸形的发病率呈稳步上升趋势。目前的发病率接近千分之二。遗传是最重要的病因因素，根据腭裂类型不同，可能导致25%至50%的病例发病，而外部因素的影响性质仍不明朗。文中给出了经验性风险数据以及一些腭裂综合征的例子。
