风疹疫苗接种最佳年龄的进一步评估。

Further evaluation of the optimum age for rubella vaccine administration.

作者信息

Wilkins J, Wehrle P F

出版信息

Am J Dis Child. 1979 Dec;133(12):1237-9. doi: 10.1001/archpedi.1979.02130120029004.

DOI:10.1001/archpedi.1979.02130120029004

Abstract

The hemagglutination-inhibition (HI) antibody responses of 452 children to HPV-77, DE5 rubella vaccine were studied. Results indicated that seroconversion rates and geometric mean titers in infants inoculated at 12 through 14 months of age are comparable with those achieved in older children. "Vaccine failures" seem to occur randomly in vaccinees after 1 year of age; the infectivity of individual vaccines is questioned. The persistence of HI antibody was evaluated through serial sampling up to three years postinoculation.

摘要

对452名儿童针对HPV - 77、DE5风疹疫苗的血凝抑制（HI）抗体反应进行了研究。结果表明，12至14个月龄接种疫苗的婴儿的血清转化率和几何平均滴度与大龄儿童的相当。“疫苗接种失败”似乎在1岁以后的受种者中随机发生；单个疫苗的传染性受到质疑。通过接种后长达三年的连续采样评估了HI抗体的持久性。