Grillner L
J Infect Dis. 1976 Jun;133(6):637-41. doi: 10.1093/infdis/133.6.637.
The persistence of antibodies was studied in 143 women two years after postpartum rubella vaccination. In addition, the effect of intranasal revaccination with the RA 27/3 strain was studied in 99 women after two years. All women had responded to primary immunization with the development of hemagglutination-inhibiting antibodies. Intranasal revaccination resulted in a significant rise in titer of hemagglutination-inhibiting antibodies in 9% of the vaccinees who received the RA 27/3 strain compared with 53% and 24% of those who received the Cendehill and HPV-77 DE-5 vaccines, respectively. The difference between the response in the RA 27/3 group and that in the C Cendehill group was statistically significant (P less than 0.001), as was the difference between the response of the latter group and that of the HPV-77 DE-5 group (0.03 greater than P greater than 0.01). The susceptibility to intranasal challenge was found to be related to low levels of serum hemagglutination-inhibiting antibodies. The titers of hemagglutination-inhibiting antibody were well maintained during the follow-up period, but three of the 52 Cendehill vaccinees had titers of less than 1:10 after two years.
对143名女性在产后风疹疫苗接种两年后抗体的持续存在情况进行了研究。此外，对99名女性在两年后用RA 27/3毒株进行鼻内再接种的效果进行了研究。所有女性在初次免疫后均产生了血凝抑制抗体。与分别接受Cendehill和HPV - 77 DE - 5疫苗的接种者中53%和24%的人相比，接受RA 27/3毒株的接种者中有9%在鼻内再接种后血凝抑制抗体滴度显著升高。RA 27/3组与Cendehill组的反应差异具有统计学意义（P小于0.001），后一组与HPV - 77 DE - 5组的反应差异也具有统计学意义（0.03大于P大于0.01）。发现对鼻内激发的易感性与血清血凝抑制抗体水平低有关。在随访期间，血凝抑制抗体滴度保持良好，但52名接种Cendehill疫苗的女性中有3人在两年后滴度低于1:10。
