Mercer H D, Teske R H, Helferich W G, Showalter D H
Am J Vet Res. 1979 Apr;40(4):567-70.
The double-isotope single-injection method to estimate renal function which utilizes the radiolabeled chemicals [131I]sodium iodohippurate and [125I]sodium iothalamate was evaluated in swine. A total of 46 normal, cross-bred swine were used to determine the applicability of this method for measuring the glomerular filtration rate and effective renal plasma flow. The mean glomerular filtration rate in pigs was determined to be 5.33 +/- 0.82 ml/kg of body weight/minute for [125I]sodium iothalamate with a biological half-life (T 1/2) of 39.18 +/- 7.44 minutes. The mean effective renal plasma flow was determined to be 19.25 +/- 3.12 ml/kg of body weight/minute for [313I]sodium iodohippurate, with a T 1/2 of 18.45 +/- 1.74 minutes. These values are more closely related to the glomerular filtration and effective renal plasma flow values reported for dogs and cats than they are to values reported for man. The method is rapid and reliable; results are available 6 to 8 hours after the experiment. This method is advantageous when information about renal function variables is a prerequisite to pharmacokinetic or toxicologic studies.
利用放射性标记化学物质[131I]碘马尿酸钠和[125I]碘他拉酸钠的双同位素单次注射法评估肾功能，该方法在猪身上进行了评估。总共46头正常杂交猪被用于确定该方法测量肾小球滤过率和有效肾血浆流量的适用性。对于[125I]碘他拉酸钠，猪的平均肾小球滤过率为5.33±0.82毫升/千克体重/分钟，生物半衰期（T 1/2）为39.18±7.44分钟。对于[131I]碘马尿酸钠，平均有效肾血浆流量为19.25±3.12毫升/千克体重/分钟，T 1/2为18.45±1.74分钟。这些值与报道的狗和猫的肾小球滤过率和有效肾血浆流量值的关系，比与报道的人类值的关系更为密切。该方法快速可靠；实验后6至8小时即可获得结果。当肾功能变量信息是药代动力学或毒理学研究的先决条件时，该方法具有优势。
