Suh B, Stephens J L, Kunin C M
Antimicrob Agents Chemother. 1979 Oct;16(4):519-22. doi: 10.1128/AAC.16.4.519.
To better define a minimal but optimal dose of oral neomycin to suppress ammonia production by bowel flora, several dosage regimens were examined in normal healthy volunteers. Fecal urease activity was quantitatively determined and was used as an indirect measure of intrinsic ammonia production by bowel flora. Large doses of neomycin were found to exert inhibition of fecal urease for many days. There was considerable variation in enzymatic activity among subjects even after adjustments were made for protein content of the stool. Depending on the dose, there was a 1- to 3-day lag in neomycin effect on stool urease activity and several days of continued effect. The most effective regimen of those studied was a loading dose of 6 g of neomycin given in three divided doses on day 1, followed by 1 g twice daily.
为了更好地确定口服新霉素抑制肠道菌群产氨的最小但最佳剂量，在正常健康志愿者中研究了几种给药方案。定量测定粪便脲酶活性，并将其作为肠道菌群内源性产氨的间接指标。发现大剂量新霉素可抑制粪便脲酶活性达多日。即使对粪便蛋白质含量进行校正后，受试者之间的酶活性仍存在相当大的差异。根据剂量不同，新霉素对粪便脲酶活性的作用有1至3天的延迟，且有几天的持续作用。所研究的最有效方案是第1天给予6g新霉素负荷剂量，分三次服用，随后每日两次，每次1g。
