Wexler B C
Atherosclerosis. 1979 Nov;34(3):277-90. doi: 10.1016/s0021-9150(79)80006-4.
Virgin, male, Sprague--Dawley rats were observed from 3 to 34 months of age. Systolic blood pressure rose progressively with age, reaching abnormally elevated levels in some, becoming abnormally low in others. The old virgin males gained and then lost weight progressively with age, their pituitary and adrenal glands were heavier than young rats, and their thymi were greatly involuted. The old virgin rats manifested fatty infiltration of the liver and islet beta cell degranulation concomitant with hyperlipidemia, hyperglycemia, and elevated circulating corticosterone levels. Spontaneous arteriosclerosis, identical to that found in younger breeder rats was found in these old virgin males. Therefore, the vascular and other degenerative changes found in young breeder rats in considered to be an example of accelerated arterial disease.
对3至34月龄的雄性斯普拉格-道利（Sprague-Dawley）未交配大鼠进行观察。收缩压随年龄逐渐升高，部分大鼠血压异常升高，部分则异常降低。老龄未交配雄性大鼠的体重随年龄先增加后减少，其垂体和肾上腺比年轻大鼠的更重，胸腺则明显萎缩。老龄未交配大鼠出现肝脏脂肪浸润和胰岛β细胞脱颗粒，同时伴有高脂血症、高血糖和循环皮质酮水平升高。在这些老龄未交配雄性大鼠中发现了与年轻繁殖大鼠相同的自发性动脉硬化。因此，年轻繁殖大鼠中发现的血管及其他退行性变化被认为是动脉疾病加速的一个例子。
