Cevallos W H, Holmes W L, Myers R N, Smink R D
Atherosclerosis. 1979 Nov;34(3):303-17. doi: 10.1016/s0021-9150(79)80008-8.
The effect of saturated (beef tallow) and polyunsaturated (corn oil) fat diets on plasma cholesterol, bile flow and composition, and excretion of fecal steroids, was studied in 5 female and 6 male miniature swine. The animals were fitted with a modified Baldwin T-tube in the common bile duct for bile sampling and a catheter in the duodenum for reinfusion. Plasma cholesterol levels were increased by beef tallow and decreased by corn oil. Both fats caused an increase in the secretion of bile, biliary lipids and bile acid pool size. The increases were significant when the source of fat was corn oil. The fecal neutral steroid excretion measured in the male swine was increased by both fats. However, only the polyunsaturated fat diet caused a significant increase in the fecal acidic steroid excretion.
在5只雌性和6只雄性小型猪身上研究了饱和脂肪（牛脂）和多不饱和脂肪（玉米油）饮食对血浆胆固醇、胆汁流量和成分以及粪便类固醇排泄的影响。这些动物在胆总管中安装了改良的鲍德温T型管用于胆汁采样，并在十二指肠中插入导管用于再输注。牛脂使血浆胆固醇水平升高，玉米油使其降低。两种脂肪都导致胆汁、胆汁脂质分泌增加以及胆汁酸池大小增加。当脂肪来源为玉米油时，这些增加具有显著性。雄性猪中测得的粪便中性类固醇排泄量在两种脂肪饮食下均增加。然而，只有多不饱和脂肪饮食导致粪便酸性类固醇排泄量显著增加。
