Gilliland S E, Nelson C R, Maxwell C
Appl Environ Microbiol. 1985 Feb;49(2):377-81. doi: 10.1128/aem.49.2.377-381.1985.
Considerable variation was found among strains of Lactobacillus acidophilus isolated from the fecal flora of pigs with regard to the ability to grow well in the presence of bile and to assimilate cholesterol from a laboratory growth medium. The uptake of cholesterol occurred only when the culture(s) was growing in the presence of bile under anaerobic conditions. Consumption of L. acidophilus RP32, which was selected for its ability to grow well in the presence of bile and to assimilate cholesterol from the laboratory medium, significantly inhibited increases in serum cholesterol levels of pigs (P less than 0.05) fed a high-cholesterol diet. Consumption of L. acidophilus P47, which was selected for its ability to grow in the presence of bile and lack of ability to remove cholesterol from the growth medium, failed to have a similar effect. This indicates that certain strains of L. acidophilus act directly on cholesterol in the gastrointestinal tract, and thus may be beneficial in reducing serum cholesterol levels.
从猪粪便菌群中分离出的嗜酸乳杆菌菌株，在胆汁存在下良好生长以及从实验室生长培养基中同化胆固醇的能力方面存在相当大的差异。只有当培养物在厌氧条件下胆汁存在时生长，胆固醇的摄取才会发生。选择在胆汁存在下生长良好且能从实验室培养基中同化胆固醇的嗜酸乳杆菌RP32供猪食用，显著抑制了喂食高胆固醇饮食的猪血清胆固醇水平的升高（P小于0.05）。选择在胆汁存在下生长但缺乏从生长培养基中去除胆固醇能力的嗜酸乳杆菌P47供猪食用，未能产生类似效果。这表明某些嗜酸乳杆菌菌株直接作用于胃肠道中的胆固醇，因此可能有助于降低血清胆固醇水平。
