Mattock M B, Fuller J H, Maude P S, Keen H
Atherosclerosis. 1979 Dec;34(4):437-49. doi: 10.1016/0021-9150(79)90068-6.
Serum lipoproteins, separated by preparative ultracentrifugation and the activity of the plasma enzyme lecithin: cholesterol acyltransferase (LCAT) have been measured in insulin-dependent diabetics, non-insulin-dependent diabetics and in age-matched non-diabetic controls. In the insulin-dependent diabetics, mean total serum cholesterol and high density lipoprotein cholesterol (HDL-C) concentrations were significantly higher than in controls. Non-insulin-dependent diabetics had significantly raised total triglycerides and cholesterol, but HDL-C levels were essentially normal. The increased low density lipoprotein cholesterol (LDL-C) in both diabetic groups was statistically significant in men. A methodological study of HDL separation techniques was carried out to facilitate interpretation of these findings. Mean LCAT activity, by a method reflecting combined enzyme and substrate effects was significantly increased in these diabetic groups. The results confirm recent reports of a raised HDL-C in those insulin-dependent diabetics who are prone to coronary heart disease.
通过制备性超速离心分离的血清脂蛋白以及血浆卵磷脂胆固醇酰基转移酶（LCAT）的活性，已在胰岛素依赖型糖尿病患者、非胰岛素依赖型糖尿病患者以及年龄匹配的非糖尿病对照组中进行了测定。在胰岛素依赖型糖尿病患者中，血清总胆固醇和高密度脂蛋白胆固醇（HDL-C）的平均浓度显著高于对照组。非胰岛素依赖型糖尿病患者的总甘油三酯和胆固醇显著升高，但HDL-C水平基本正常。两组糖尿病患者中低密度脂蛋白胆固醇（LDL-C）的升高在男性中具有统计学意义。为便于解释这些结果，开展了一项HDL分离技术的方法学研究。通过一种反映酶和底物综合效应的方法测定，这些糖尿病组的平均LCAT活性显著增加。结果证实了最近关于那些易患冠心病的胰岛素依赖型糖尿病患者HDL-C升高的报道。
