Bachem M G, Paschen K, Strobel B, Jastram H U, Janssen E G, Dati F
Klin Wochenschr. 1982 May 17;60(10):497-503. doi: 10.1007/BF01756095.
Based upon a 3-week observation at a summer camp for diabetic children whose medical therapy, metabolic rate, diet, physical exercise and special training could be closely monitored, the following parameters were measured at the beginning and at the end: In whole blood and young erythrocytes HbA1, in serum triglycerides, cholesterol, HDL-cholesterol, as well as apolipoprotein A and B. From these data, the LDL-cholesterol and the atherosclerosis indices (LDL-cholesterol/HDL-cholesterol and apolipoprotein B/apolipoprotein A) were determined. The following results were obtained: the parameters of lipid-metabolism recognized as risk factors for vascular complications such as triglycerides, cholesterol, LDL-cholesterol and apolipoprotein B, were the same as those obtained from a control group of healthy children in the same age. Using HbA1 as the basis for the observations, the risk factors were reduced by normalisation of glucose metabolism. On the other hand, the apolipoprotein A and HDL-cholesterol, well known as protective factors against atherosclerosis, are higher than in the control group and show a further increase with metabolic normalisation. The conclusion is: If medical therapy, metabolic rate, diet, physical exercise and special training are better controlled, the risk of diabetes developing macroangiopathy can be diminished.
在一个糖尿病儿童夏令营进行了为期3周的观察，期间对这些儿童的药物治疗、代谢率、饮食、体育锻炼和特殊训练进行密切监测，并在开始和结束时测量了以下参数：全血和年轻红细胞中的糖化血红蛋白A1、血清中的甘油三酯、胆固醇、高密度脂蛋白胆固醇以及载脂蛋白A和B。根据这些数据，计算出低密度脂蛋白胆固醇和动脉粥样硬化指数（低密度脂蛋白胆固醇/高密度脂蛋白胆固醇以及载脂蛋白B/载脂蛋白A）。结果如下：被认为是血管并发症危险因素的脂质代谢参数，如甘油三酯、胆固醇、低密度脂蛋白胆固醇和载脂蛋白B，与同龄健康儿童对照组的结果相同。以糖化血红蛋白A1作为观察基础，通过葡萄糖代谢正常化，危险因素降低。另一方面，众所周知的抗动脉粥样硬化保护因子载脂蛋白A和高密度脂蛋白胆固醇高于对照组，并且随着代谢正常化进一步升高。结论是：如果药物治疗、代谢率、饮食、体育锻炼和特殊训练得到更好的控制，糖尿病发生大血管病变的风险可以降低。
