Vianello M G, Fasce L C, Mura M S, Andreoni G, Scalise G
Boll Ist Sieroter Milan. 1979 Jul 31;58(3):266-72.
A highly significant incidence, ranging from 3% to 20% of chromosomal stickiness and agglutination, has been found in 100% of patients with viral hepatitis HBsAg positive and, in lower grade, in carriers of HBsAg. Whereas, such a structural aberration does not occur in normal subjects. No statistical difference has been found as regard chromosomal fragmentation, presence of incisures and numerical anomalies. A possible role of the observed alterations for an impaired cellular immune function observed in healthy HBsAg carriers has been discussed.
在100%的HBsAg阳性病毒性肝炎患者中发现了3%至20%的染色体粘连和凝集的高显著发生率，而在HBsAg携带者中发生率较低。然而，正常受试者中未出现这种结构畸变。在染色体断裂、切迹的存在和数目异常方面未发现统计学差异。已讨论了观察到的改变对健康HBsAg携带者中观察到的细胞免疫功能受损的可能作用。
