Kleĭmenova N N, Osmrovskaia R U, Arefolov V A
Biull Eksp Biol Med. 1979 Sep;88(9):358-61.
The ultrastructure of myocytes of the rat myocardium and skeletal muscles was studied in the control during physical exercise and under conditions of two-week sodium hydroxybutyrate pretreatment. It was shown that single maximum physical exercise caused significant changes in the fine structure of cardiomyocytes and somewhat less changes in a pronounced intermyofibrillar edema, the swelling of mitochondria and an acute fall of the glycogen level. A two-week sodium hydroxybutyrate pretreatment prevented the changes in the myocytes. The observed structure normalization induced by the drug is likely to be due to the specific nature of its metabolic transformation and to the effect on the energy exchange.
在体力锻炼的对照阶段以及两周丁酸钠预处理的条件下，对大鼠心肌和骨骼肌的肌细胞超微结构进行了研究。结果表明，单次最大体力锻炼导致心肌细胞的精细结构发生显著变化，而肌原纤维间明显水肿、线粒体肿胀以及糖原水平急剧下降的变化则稍小一些。两周的丁酸钠预处理可防止肌细胞发生这些变化。药物引起的观察到的结构正常化可能归因于其代谢转化的特殊性质以及对能量交换的影响。
