Kamysheva V A, Ostrovskaia R U
Biull Eksp Biol Med. 1980;89(1):25-7.
The experiments on rats exposed to compulsory swimming have shown the normalizing effect of sodium hydroxybutyrate with respect to one of the biochemical indices of physical overwork: the ammonia level in cross-striated muscles. In control rats who had not received the drug, the swimming induced a significant (more than twofold) increase in the muscle tissue ammonia level, whereas animals preventively treated with sodium hydroxybutyrate (single administration or two-week course) demonstrated no ammonia accumulation. It is suggested that sodium hydroxybutyrate preventing the toxic effect of one of the end products of nitrogen metabolism may reduce afteraction of muscular overwork.
对被迫游泳的大鼠进行的实验表明，羟基丁酸钠对体力过度劳累的一项生化指标具有正常化作用：横纹肌中的氨水平。在未接受该药物的对照大鼠中，游泳导致肌肉组织氨水平显著升高（超过两倍），而预先用羟基丁酸钠治疗（单次给药或为期两周的疗程）的动物未出现氨积累。提示羟基丁酸钠可预防氮代谢终产物之一的毒性作用，可能减轻肌肉过度劳累的后遗症。
