磷脂酰丝氨酸脂质体的药理作用：溶血磷脂酰丝氨酸的作用
Pharmacological effects of phosphatidylserine liposomes: the role of lysophosphatidylserine.
作者信息
Bigon E, Boarato E, Bruni A, Leon A, Toffano G
出版信息
Br J Pharmacol. 1979 Dec;67(4):611-6. doi: 10.1111/j.1476-5381.1979.tb08708.x.
Abstract
- Unique among the phospholipids, phosphatidylserine depresses brain energy metabolism when injected intravenously into mice in the form of sonicated liposomes. The possibility that this effect results from a metabolic transformation of phosphatidylserine is examined in this paper. 2. A strong enhancement of the phosphatidylserine effect is induced by the incubation of liposomes with rat serum. Similar phosphatidylserine activation is observed after the incubation of the phospholipid with purified phospholipase A2 from pancreas. In both cases phosphatidylserine is split into the deacylated derivative, lysophosphatidylserine. 3. Lysophosphatidylserine reproduces with greater efficacy the effect of phosphatidylserine on brain energy metabolism. Other lysophospholipids are not effective. 4. It is concluded that the pharmacological effects of phosphatidylserine liposomes is due to the generation of lysophosphatidylserine.
摘要
- 磷脂酰丝氨酸在磷脂中独具特色，当以超声处理的脂质体形式静脉注射到小鼠体内时，会抑制脑能量代谢。本文研究了这种效应是否由磷脂酰丝氨酸的代谢转化引起。2. 脂质体与大鼠血清孵育可强烈增强磷脂酰丝氨酸的效应。磷脂与来自胰腺的纯化磷脂酶A2孵育后，也观察到类似的磷脂酰丝氨酸活化现象。在这两种情况下，磷脂酰丝氨酸都被分解为脱酰基衍生物溶血磷脂酰丝氨酸。3. 溶血磷脂酰丝氨酸能更有效地重现磷脂酰丝氨酸对脑能量代谢的影响。其他溶血磷脂则无效。4. 得出的结论是，磷脂酰丝氨酸脂质体的药理作用归因于溶血磷脂酰丝氨酸的产生。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The preparation and properties of lysophosphatidylserine.溶血磷脂酰丝氨酸的制备及其性质
Biochem J. 1962 Jun;83(3):498-502. doi: 10.1042/bj0830498.
3
Phosphorus assay in column chromatography.柱色谱法中的磷测定
J Biol Chem. 1959 Mar;234(3):466-8.
4
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
5
Metabolism of labeled lysolecithin, lysophosphatidyl ethanolamine and lecithin in the rat.大鼠体内标记溶血卵磷脂、溶血磷脂酰乙醇胺和卵磷脂的代谢
Biochim Biophys Acta. 1966 Feb 1;116(1):95-107. doi: 10.1016/0005-2760(66)90095-6.
6
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
7
[Rat blood plasma phospholipase A. Kinetics and properties. Existance of an inactive precursor].[大鼠血浆磷脂酶A。动力学与特性。无活性前体的存在]
Bull Soc Chim Biol (Paris). 1969 Oct;51(5):863-73.
8
The uptake and metabolism of plasma lysophosphatidylcholine in vivo by the brain of squirrel monkeys.松鼠猴大脑在体内对血浆溶血磷脂酰胆碱的摄取与代谢
Biochem J. 1972 Nov;130(2):557-67. doi: 10.1042/bj1300557.
9
Pharmacological effects of phosphatidylserine liposomes.磷脂酰丝氨酸脂质体的药理作用。
Nature. 1976 Mar 25;260(5549):331-3. doi: 10.1038/260331a0.
10
Solubilization of membranes by detergents.用去污剂溶解细胞膜。
Biochim Biophys Acta. 1975 Mar 25;415(1):29-79. doi: 10.1016/0304-4157(75)90016-7.
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