Bigon E, Bruni A, Mietto L, Toffano G
Br J Pharmacol. 1980 May;69(1):11-2. doi: 10.1111/j.1476-5381.1980.tb10876.x.
In the presence of mouse plasma, lysophosphatidylserine stimulates histamine secretion from isolated mast cells. The extensive modification of carbohydrate metabolism produced by lysophosphatidylserine in mice was largely prevented by the antihistaminic drug, pyrilamine. However, to prevent completely the change in carbohydrate metabolism induced by lysophosphatidylserine the administration of an antihistamine and an adrenoceptor antagonist was required. It is concluded that the effect of lysophosphatidylserine in mice is due to release of intracellular amines. Histamine and catecholamines are involved.
在存在小鼠血浆的情况下，溶血磷脂酰丝氨酸刺激分离的肥大细胞分泌组胺。溶血磷脂酰丝氨酸在小鼠体内引起的碳水化合物代谢的广泛改变在很大程度上被抗组胺药物吡苄明所阻止。然而，为了完全防止溶血磷脂酰丝氨酸诱导的碳水化合物代谢变化，需要同时给予抗组胺药和肾上腺素能受体拮抗剂。得出的结论是，溶血磷脂酰丝氨酸在小鼠体内的作用是由于细胞内胺的释放。组胺和儿茶酚胺都参与其中。
