肿瘤促凝血酶原激酶在肺转移灶分布模式中的作用。
Role of tumor thromboplastin in the mode of distribution of metastatic foci in the lung.
作者信息
Kohga S, Tanaka K
出版信息
Gan. 1979 Oct;70(5):615-9.
Crude tumor cell extract from rat ascites hepatoma AH130 revealed a high thromboplastic activity. Intravenous injection of the extract caused widespread thrombus formation in the capillaries, arterioles, and arteries of the lung. Intravenous inoculation of AH130 after an injection of the tumor cell extract produced metastatic foci in the larger arteries, compared with the case injected with only AH130 which developed metastatic foci mainly in and around the alveolar septa. These results suggest the role of tumor thromboplastin material in the mode of distribution of metastatic foci in the lung.
大鼠腹水肝癌AH130的粗制肿瘤细胞提取物显示出较高的促凝血活性。静脉注射该提取物会导致肺部毛细血管、小动脉和动脉广泛形成血栓。在注射肿瘤细胞提取物后静脉接种AH130，与仅注射AH130的情况相比，在较大动脉中产生了转移灶，仅注射AH130的情况下转移灶主要出现在肺泡隔及其周围。这些结果表明肿瘤促凝血物质在肺部转移灶分布方式中的作用。
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