Naito S, Kinjo M, Tanaka K
Acta Pathol Jpn. 1980 Jul;30(4):541-7. doi: 10.1111/j.1440-1827.1980.tb01349.x.
Three cultured cell lines of human lung cancer with varied degrees of thromboplastic and fibrinolytic activities were injected subcutaneously or intravenously into congenitally athymice nude mice, and their fate was observed with light and electron microscopes. All the cell lines formed solid tumor masses at the sites of subcutaneous injection. When the cancer cells with high or moderate thromboplastic activity were injected intravenously, marked platelet aggregation and fibrin deposition, followed by neutrophilic infiltration, were seen around the cancer cells arrested in pulmonary arterioles or capillaries. Platelet aggregation and fibrin deposition were less conspicuous, when the cancer cells with low thromboplastic activity were injected. No metastatic foci were found 2 weeks after the intravenous injection of each cancer cell line. These results suggest that thromboplastic activity of human cancer cells is closely related to thrombus formation at the sites of lodgement and that thrombus develops without participation of immunological mechanisms.
将三种具有不同程度促凝血和纤溶活性的人肺癌培养细胞系皮下或静脉注射到先天性无胸腺裸鼠体内，并用光学显微镜和电子显微镜观察其转归。所有细胞系在皮下注射部位均形成实体瘤块。当具有高或中度促凝血活性的癌细胞静脉注射时，在肺小动脉或毛细血管中滞留的癌细胞周围可见明显的血小板聚集和纤维蛋白沉积，随后有嗜中性粒细胞浸润。当注射具有低促凝血活性的癌细胞时，血小板聚集和纤维蛋白沉积则不那么明显。在静脉注射每种癌细胞系2周后均未发现转移灶。这些结果表明，人癌细胞的促凝血活性与着床部位的血栓形成密切相关，并且血栓的形成无需免疫机制的参与。
