Cruceanu A, Babes V T, Lenkei R, Cepănaru S, Kloos G
Med Microbiol Immunol. 1975 Jul 2;161(3):221-3. doi: 10.1007/BF02121012.
From 200 acute viral hepatitis patients serum samples were collected successively, at various intervals. In 192 patients one single hepatitis B-antigen (HB-Ag) subdeterminant ("ad" in 37.6% and "ay" in 62.4% of the cases) occurred and persisted during the entire course of the disease. The remained 8 patients (4%) showed an alternation of HB-Ag subdeterminants. The possible causes of this alternation are discussed in detail.
从200例急性病毒性肝炎患者中,在不同间隔时间连续采集血清样本。192例患者出现单一的乙肝抗原(HB-Ag)亚决定簇(37.6%的病例为“ad”,62.4%的病例为“ay”),并在疾病全过程中持续存在。其余8例患者(4%)显示HB-Ag亚决定簇出现交替变化。详细讨论了这种交替变化的可能原因。