Davies H, Oliver G C, Rappoport W J, Gazetopoulos N
Br Heart J. 1970 Nov;32(6):747-53. doi: 10.1136/hrt.32.6.747.
Post-operative data have been presented in seven patients with atrial septal defect. In five of them, residual patency of the atrial septum was found at cardiac catheterization, but in two the defect had been closed. All showed evidence of 'left-sided dysfunction', expressed either as an increase in the pulmonary arterial wedge pressure or the left ventricular end-diastolic pressure or both. The reasons for these findings are not clear, though in several there were indications of impaired right ventricular compliance and possible transmission of raised right-sided pressures to the left side of the heart through a still patent atrial septum. This could not, however, be the mechanism in all cases, and dysfunction of the left ventricle has been seen in two patients in whom the defect was securely closed. The cause of this phenomenon in these selected cases remains obscure.
已公布7例房间隔缺损患者的术后数据。其中5例在心脏导管检查时发现房间隔存在残余通畅，但有2例缺损已闭合。所有患者均显示出“左侧功能障碍”的迹象，表现为肺动脉楔压升高、左心室舒张末期压力升高或两者均升高。尽管在一些患者中有右心室顺应性受损的迹象，并且可能通过仍未闭合的房间隔将升高的右侧压力传递至心脏左侧，但这些发现的原因尚不清楚。然而，这不可能是所有病例的机制，并且在2例缺损已牢固闭合的患者中也发现了左心室功能障碍。在这些选定病例中这种现象的原因仍然不明。
