Lueker R D, Vogel J H, Blount S G
Br Heart J. 1970 Nov;32(6):779-82. doi: 10.1136/hrt.32.6.779.
Eight patients with mild to moderate valvular pulmonary stenosis underwent serial physiological studies before surgical intervention. Average pulmonary valve area at the initial study was 0.59 cm.2 and at the second study (average 7.8 years later) was 1.09 cm.2, resulting in an average increase of 0.49 cm.2 (p greater than 0.05). In normal subjects during early years the pulmonary valve area increases linearly with age and with increasing body surface area. Though patients with valvular pulmonary stenosis have smaller valve orifices, they also show an increase in valve size with increasing age and with increasing body growth. The greatest increase in valve area was observed in 4 patients (all under age 6) in whom body surface area increased more than 70 per cent.
8例轻至中度瓣膜性肺动脉狭窄患者在手术干预前接受了系列生理学研究。初始研究时肺动脉瓣平均面积为0.59平方厘米，第二次研究时（平均7.8年后）为1.09平方厘米，平均增加了0.49平方厘米（p>0.05）。在正常受试者早年，肺动脉瓣面积随年龄和体表面积增加呈线性增加。虽然瓣膜性肺动脉狭窄患者的瓣口较小，但随着年龄增长和身体发育，其瓣膜大小也会增加。在4例（均未满6岁）体表面积增加超过70%的患者中观察到瓣膜面积增加最大。
