Rothwell N J, Stock M J
J Comp Physiol Psychol. 1979 Dec;93(6):1024-34. doi: 10.1037/h0077631.
Adult male rats were made obese either by tube feeding varying fractions (34%, 47%, 68% or 75%) of their normal food intake or by offering them a varied and palatable diet (cafeteria diet). After 17--30 days of these regimens, the treatments were withdrawn, and the animals were allowed free access to the normal stock diet. Tube-fed animals precisely adjusted voluntary food intake to compensate for the energy delivered by tube but nevertheless became obese as a result of an increased metabolic efficiency. Cafeteria-fed rats were hyperphagic and became obese without any apparent change in metabolic efficiency. Recovery from obesity was more rapid in the cafeteria animals and was due to a pronounced increase in heat production as well as concomitant hypophagia. Animals previously made obese by tube feeding exhibited hypophagia and returned to normal weight without any change in heat production. The relevance of these results to the concept of lipostasis and the relative roles of energy intake and expenditure in the regulation of energy balance are discussed.
一是通过管饲给予其正常食物摄入量的不同比例（34%、47%、68%或75%），二是给予它们多样化且美味的饮食（自助餐式饮食）。在这些方案实施17至30天后，停止处理，让动物自由摄取正常的储备食物。通过管饲的动物精确地调整了自愿食物摄入量，以补偿通过管饲提供的能量，但由于代谢效率提高，它们仍然变得肥胖。食用自助餐式饮食的大鼠食欲亢进，在代谢效率没有任何明显变化的情况下变得肥胖。自助餐式饮食的动物从肥胖中恢复得更快，这是由于产热显著增加以及随之而来的食欲减退。先前通过管饲变得肥胖的动物出现食欲减退，并恢复到正常体重，产热没有任何变化。讨论了这些结果与脂肪稳定概念的相关性以及能量摄入和消耗在能量平衡调节中的相对作用。
