Rothwell N J, Stock M J
J Nutr. 1982 Mar;112(3):426-35. doi: 10.1093/jn/112.3.426.
Weanling rats fed a palatable "cafeteria" diet consumed 40-70% more energy than stock fed controls but also showed a marked (80%) increase in energy expenditure (diet-induced thermogenesis) so that body weight and body energy gain were almost identical in both groups. Animals previously fed the cafeteria diet for 30 days after weaning exhibited lower weight gains when re-exposed to the cafeteria diet at 90 days of age than either naive rats or rats which had been fed the cafeteria diet continuously from weaning. Rats which had been undernourished for 30 days form weaning and allowed to recover for 30 days showed similar responses to the cafeteria diet as normal animals. Hypertrophy of brown adipose tissue (BAT) was seen in all cafeteria fed rats but hyperplasia (increased DNA content) was observed only in rats which had been overfed in early life. These results suggest that overfeeding young, weanling rats can result in a lower fat content, a greater thermogenic capacity and resistance to obesity later in life and may be due to a permanent increase in BAT cell number.
用美味的“自助式”饮食喂养的断奶大鼠比食用普通饲料的对照组多消耗40%-70%的能量，但能量消耗（饮食诱导产热）也显著增加（80%），因此两组大鼠的体重和身体能量增加几乎相同。断奶后先喂食30天自助式饮食的动物，在90日龄再次接触自助式饮食时，体重增加低于未接触过的大鼠或从断奶起就持续喂食自助式饮食的大鼠。断奶后营养不良30天并恢复30天的大鼠，对自助式饮食的反应与正常动物相似。所有喂食自助式饮食的大鼠都出现了棕色脂肪组织（BAT）肥大，但只有在生命早期过度喂养的大鼠中观察到了增生（DNA含量增加）。这些结果表明，幼年断奶大鼠过度喂养可导致后期脂肪含量降低、产热能力增强和对肥胖的抵抗力增强，这可能是由于BAT细胞数量永久性增加所致。
