Stahl J M, Ellen P
J Comp Physiol Psychol. 1979 Dec;93(6):1145-53. doi: 10.1037/h0077639.
The purpose of this study was to determine whether behavioral sparing would be demonstrated when septal lesions occurred prior to the age at which the tested behavior first appears in normal rats. Rats given septal lesions at 1 day or 7 days after birth performed at approximately chance on the Maier three-table task when tested at 90 days of age. Rats that had control electrode insertions at the same ages performed at a level similar to normal animals. Animals given septal lesions at either age explored significantly more than did control animals. Results are discussed in terms of the constancy over time of the septal contribution to performance on the three-table task and the involvement of the septum and hippocampus in the processing of spatial information.
本研究的目的是确定当在正常大鼠首次出现被测试行为的年龄之前发生隔区损伤时，是否会表现出行为保留。出生后1天或7天接受隔区损伤的大鼠在90日龄接受测试时，在迈尔三桌任务中的表现大致处于随机水平。在相同年龄进行对照电极植入的大鼠表现水平与正常动物相似。在这两个年龄接受隔区损伤的动物探索行为明显多于对照动物。根据隔区对三桌任务表现的贡献随时间的稳定性以及隔区和海马体在空间信息处理中的参与情况对结果进行了讨论。
