Gittis A G, Gordon M
J Comp Physiol Psychol. 1977 Feb;91(1):94-106. doi: 10.1037/h0077309.
At 7 days of age, rats received lesions of the septal nuclei or control operations. The rats received 30 hr of training on a schedule that differentially reinforced low rates of responding (DRL 20 sec), 1 hr per day, beginning at either 27 or 96 days of age. At 126 days of age, all subjects received 10 additional training sessions. After operant testing, all subjects were tested on spontaneous alternation, spatial reversal, and passive avoidance. Results indicated that on a DRL 20-sec schedule subjects that received lesions of the septum neonatally and were tested at different ages performed in a similar manner. Approximately 50% of the subjects with lesions of the septal nuclei reached efficiency levels comparable with those of normal controls. When tested for retention, these efficient subjects still performed similarly to normal subjects. Subjects with septal lesions were facilitated in the acquisition of a spatial habit, were deficient in spatial habit reversal, were less likely to demonstrate spontaneous alternation, and were deficient in passive avoidance. It was concluded that neonatal lesions of the septal nuclei produce permanent behavioral impairments on a dirersity of measures and that although juvenile animals with limbic system damage often manifest behaviors different from adult subjects, the difference was not evident during operant testing.
在7日龄时，大鼠接受了隔核损伤或对照手术。这些大鼠从27日龄或96日龄开始，按照每天1小时、以不同方式强化低反应率（DRL 20秒）的时间表接受30小时的训练。在126日龄时，所有受试者又接受了10次训练。在操作性测试后，所有受试者都接受了自发交替、空间反转和被动回避测试。结果表明，在DRL 20秒的时间表上，新生期接受隔核损伤并在不同年龄进行测试的受试者表现相似。大约50%的隔核损伤受试者达到了与正常对照组相当的效率水平。在进行记忆测试时，这些高效受试者的表现仍与正常受试者相似。隔核损伤的受试者在空间习惯的习得方面得到促进，在空间习惯反转方面存在缺陷，表现出自发交替的可能性较小，并且在被动回避方面存在缺陷。得出的结论是，新生期隔核损伤会在多种测量指标上产生永久性的行为损伤，并且尽管患有边缘系统损伤的幼年动物通常表现出与成年受试者不同的行为，但在操作性测试期间这种差异并不明显。
