Toh Y C
J Endocrinol. 1979 Nov;83(2):199-203. doi: 10.1677/joe.0.0830199.
Newborn Sprague-Dawley rats of both sexes were treated with 28 micrograms thyroxine (T4) daily for the first week of life. At the age of 80 days, the secretion rate of sebum was measured from the amount of skin-surface lipids extractable by acetone and which had been produced during 2 days. Treatment with such excess amounts of T4 during the early postnatal period significantly reduced the production of sebum in both male and female rats when compared with control rats and with rats deprived of food early in life. The thyroid, the pituitary gland, the testes and the seminal vesicles were significantly smaller but the weights of the ovaries and uteri remained relatively unaffected. There was a similar ratio of sex difference in the rate of sebum secretion irrespective of treatment. It is suggested that a reduction of sebaceous response in rats made thyrotoxic with large doses of T4 early in life was probably due to a decreased secretion of thyroid hormone which is required to maintain normal activity of the sebaceous glands.
新生的雌雄Sprague-Dawley大鼠在出生后的第一周每天接受28微克甲状腺素（T4）治疗。在80日龄时，通过丙酮可提取的、在两天内产生的皮肤表面脂质的量来测量皮脂分泌率。与对照大鼠和出生早期就被剥夺食物的大鼠相比，在出生后早期用过量的T4进行治疗显著降低了雄性和雌性大鼠的皮脂分泌。甲状腺、垂体、睾丸和精囊明显较小，但卵巢和子宫的重量相对未受影响。无论治疗如何，皮脂分泌率的性别差异比例相似。有人认为，在生命早期用大剂量T4使大鼠产生甲状腺毒症时，皮脂腺反应降低可能是由于维持皮脂腺正常活动所需的甲状腺激素分泌减少所致。
