Toh Y C
J Endocrinol. 1980 May;85(2):261-5. doi: 10.1677/joe.0.0850261.
Sprague-Dawley rats were castrated either within 24 h of birth or at 4 weeks of age. Control animals were sham operated. Intact female rats were also included for comparison. Sebum production was assessed at 80 days of age by measuring the amount of skin-surface lipids that could be extracted with acetone and which had been produced during 2 days. The removal of the testes at birth reduced the activity of the sebaceous glands to level more nearly approaching that seen in the female rats whereas castration at 4 weeks of age only partially decreased the rate of sebum secretion so that it was intermediate between the male and female rats. The weights of the pituitary gland, thyroid and adrenal glands increased after castration but there were no differences between rats castrated at birth and those castrated at 4 weeks of age except in the weight of the thyroid gland. It would appear that the role of the testes in the control of the activity of the sebaceous glands is a sequential event which has already started at birth.
将出生后24小时内或4周龄的斯普拉格-道利大鼠进行阉割。对照动物进行假手术。还纳入了完整的雌性大鼠进行比较。在80日龄时，通过测量用丙酮可提取的、在2天内产生的皮肤表面脂质的量来评估皮脂分泌。出生时摘除睾丸会使皮脂腺的活性降低到更接近雌性大鼠的水平，而4周龄时阉割只会部分降低皮脂分泌率，使其介于雄性和雌性大鼠之间。阉割后垂体、甲状腺和肾上腺的重量增加，但出生时阉割的大鼠与4周龄时阉割的大鼠之间除甲状腺重量外没有差异。睾丸在控制皮脂腺活性中的作用似乎是一个从出生就已开始的连续过程。
