Hill D J
J Endocrinol. 1979 Nov;83(2):219-27. doi: 10.1677/joe.0.0830219.
The actions of rat plasma somatomedin activity dependent on growth hormone were investigated in vitro on separated zones of cartilage from the calf costochondral junction. Plasma somatomedin maximally stimulated the uptake of[3H]thymidine into cartilage cells of the proliferating region. Cartilage deeper in the growth plate possessed the highest uptake of [35S]sulphate which was also stimulated by somatomedin. Somatomedin, therefore, appears to promote both cell replication and matrix synthesis throughout the growth plate cartilage although the two processes were greatest in different cartilage regions. Growth hormone or tri-iodothyronine did not directly alter the uptake of either isotope into the growth plate cartilage.
在体外，研究了大鼠血浆中依赖生长激素的生长调节素活性对来自小牛肋软骨连接处软骨不同区域的作用。血浆生长调节素最大程度地刺激了[3H]胸腺嘧啶核苷进入增殖区软骨细胞。生长板中较深部位的软骨对[35S]硫酸盐的摄取最高，生长调节素也能刺激这种摄取。因此，生长调节素似乎能促进整个生长板软骨中的细胞复制和基质合成，尽管这两个过程在不同的软骨区域最为显著。生长激素或三碘甲状腺原氨酸不会直接改变任何一种同位素进入生长板软骨的摄取量。
