Obeso J A, Marti-Masso J F, Asin J L, Remirez M V, Irigoyen V, Iragui M, Carrera N, Teijeira J M, Teijeira J
J Neurol Sci. 1979 Nov;43(3):439-45. doi: 10.1016/0022-510x(79)90022-4.
The latencies of evoked potentials recorded at different levels of the peripheral and central nervous system by median nerve stimulation were measured before and after dialysis, and compared with similar recordings in normal volunteers. Abnormally slow conduction velocity was more often found in proximal rather than in distal segments of the peripheral pathway in patients with chronic renal failure. This abnormality was not correlated with the presence of clinical signs of neuropathy or low values of motor conduction velocity, neither was it affected by dialysis. These findings support the hypothesis of peripheral nerve dysfunction secondary to metabolic derangement in uraemic patients.
通过正中神经刺激，在透析前后测量外周和中枢神经系统不同水平记录的诱发电位潜伏期，并与正常志愿者的类似记录进行比较。慢性肾功能衰竭患者外周通路近端而非远端节段更常出现传导速度异常缓慢的情况。这种异常与神经病变的临床体征或运动传导速度低值无关，也不受透析影响。这些发现支持了尿毒症患者因代谢紊乱继发外周神经功能障碍的假说。
