McCalmon R T, Kubo R T, Grey H M
Scand J Immunol. 1975 Sep;4(5-6):613-6. doi: 10.1111/j.1365-3083.1975.tb02668.x.
Specific antisera directed against beta2-microglobulin (B2m) have been shown to inhibit completely the mixed lymphocyte reaction (MLR). However, the mechanism of inhibition has been unclear. In the present study, further experiments were performed to determine the effect of anti-B2m on both the stimulator and responder cells in an MLR. The experimental design used was that of a xenogeneic MLR, using mouse and human lymphocytes. The ffect of anti-human B2m was studied in this system. Anti-human B2m inhibited the xenogeneic MLR only when human lymphocytes were used as responder cells and did not inhibit the MLR when they were used as stimulator cells...
已证实，针对β2微球蛋白（B2m）的特异性抗血清可完全抑制混合淋巴细胞反应（MLR）。然而，抑制机制尚不清楚。在本研究中，进行了进一步实验，以确定抗B2m对MLR中刺激细胞和反应细胞的影响。所采用的实验设计是异种MLR，使用小鼠和人淋巴细胞。在此系统中研究了抗人B2m的作用。抗人B2m仅在用人淋巴细胞作为反应细胞时抑制异种MLR，而当它们用作刺激细胞时则不抑制MLR……
